Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB
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چکیده
منابع مشابه
End Binding Proteins Are Obligatory Dimers
End binding (EB) proteins are responsible for the recruitment of an array of microtubule plus-end tracking proteins (+TIPs) to growing microtubules ends. EBs encompass an N-terminal calponin homology domain that confers microtubule tip tracking activity to the protein. The C-terminal domain of EBs contains a coiled coil that mediates the parallel dimerization of EB monomers. This part of the pr...
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The biochemical activities that underlie the genetically defined activator and repressor functions of the VIVIPAROUSl (VP1) protein have resisted in vitro analysis. Here, we show that a glutathione S-transferase (GST) fusion protein, including only the highly conserved 83 domain of VP1, has a highly cooperative, sequence-specific DNA binding activity. GST fusion proteins that include larger reg...
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Equilibrium measurements of oxygen binding by 0 iron(II) and cobalt(II) picket fence porphyrins exhibit p^2, ΔΗ°, and AS° values close to those of myoglobin and cobalt myoglobin respectively. In contrast the CO affinities of simple iron(II) porphyrins are much greater than those of the hemoproteins, hemoglobin (Hb) and myoglobin (Mb). This difference is apparently caused by distal residues in H...
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In this paper we describe the MELB-MKB system, as entered in the SemEval-2007 lexical substitution task. The core of our system was the “Relatives in Context” unsupervised approach, which ranked the candidate substitutes by web-lookup of the word sequences built combining the target context and each substitute. Our system ranked third in the final evaluation, performing close to the top-ranked ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2021
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.202012710